Human Anti-Laminin 5 Autoantibodies Induce Subepidermal Blisters in an Experimental Human Skin Graft Model

Subepidermal Blistering Ex Vivo Autoantibodies to Type VII Collagen Induce Recombinant Human IgA1 and IgA2

Anti-Human Cardiac Myosin Autoantibodies

Human Anti-p68 Autoantibodies Recognize

Autoimmune phenomenaare known to occur in a large variety of human diseases (for review see reference 1) . Antibodies to self-components (autoantibodies) can be directed against organ-specific or non-organ-specific target structures and can develop transiently or persist chronically. Some are regarded as diagnostic markers for certain diseases, and some are pathogenic or contribute to disease d...

Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid.

Epidermolysis bullosa acquisita (EBA) and bullous pemphigoid (BP) are two clinically and immunologically distinct autoimmune subepidermal blistering skin diseases associated with IgG autoantibodies against the dermal-epidermal junction. BP antibodies are directed against the hemidesmosomal antigens BP180 and BP230, and those in patients with EBA target type VII collagen, a major component of an...

Antiplectin autoantibodies in subepidermal blistering diseases.

BACKGROUND Hemidesmosomal proteins may become targets of autoimmunity in subepidermal blistering diseases. Well-known recognized autoantigens are the intracellular plaque protein BP230, the transmembrane BP180 and its shed ectodomain LAD-1. OBJECTIVES To establish the prevalence of autoimmunity against plectin, another intracellular plaque protein, and to investigate its antigenic sites. ME...